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Constipation is one of several GI side effects linked to GLP-1 receptor agonists, and some research shows that its especially common with semaglutide, the active ingredient in both Ozempic (for Type 2 diabetes) and Wegovy (for weight management)

The fact that these medications completely turn off appetite at higher doses and prevent people from not only eating but drinking water creates a danger that many do not realize

In his experience, someone who has multiple medications for conditions like blood pressure, depression, and chronic pain is likely to develop issues with constipation especially if they add a GLP-1, he says

Avoid using these medicines long-term, because they can cause side effects like stomach bleeding and ulcers (sores)

Additionally, between the years 2021 and 2023, there was an estimated 60% increase in the United States in new-to-brand prescriptions for semaglutide [8]