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Description
Am J Geriatric Psychiatry
Effects of liraglutide on heart rate and heart rate variability: A randomized, double-blind, placebo-controlled crossover study
Coexpression of insulin and somatostatin has been observed in reprogrammed pancreatic organoid cells in conditions promoting differentiation (55)
Subsequent STEP trials on diabetic patients (STEP 2), added-on therapy on intensive lifestyles (STEP 3), a study in Asian people (STEP 6), a comparison study with liraglutide (STEP 8), a study in adolescents (STEP TEENS), a study in persons with heart failure with preserved ejection fraction (STEP-HFpEF), and a study assessing cardiovascular outcome (SELECT-Semaglutide Effects on Heart Disease and Stroke in Patients with Overweight or Obesity trial) showed significant benefit of semaglutide for treatment of obesity and cardiovascular diseases [31-37]
This limitation might restrict its use in the management of such cancer cases (Pappa and Alevizaki, 2013)
