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Are there GLP-1 alternatives if someone cannot safely take standard compounds
Proactive management of tirzepatide's gastrointestinal effects can reduce the risk of complications that might lead to rectal bleeding

Patients with pre-existing gastrointestinal conditions, those who have undergone bariatric surgery (who typically require specific bariatric-formulation supplements), or individuals following restrictive diets (vegetarian, vegan) may enter GLP-1 treatment with suboptimal nutrient status

However, both medication classes can affect nausea, appetite, and gastrointestinal function

Moreover, administration of Exendin-4, a GLP-1 agonist, resulted in induction of expression of genes encoding multiple cytokines and chemokines responsible for immune response (Yusta et al
