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Retatrutide has been investigated in the literature as a simultaneous agonist of the glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon (GCGR) receptors

These alternatives work through different mechanisms than prescription semaglutide and typically produce more modest effects on blood glucose control and weight management

Randomized controlled trial with measured GFR (JISSN, 2013): No change in 51Cr EDTA GFR after 12 weeks despite high protein intake

After studying data from non-clinical studies, clinical trials, post-marketing surveillance, and medical literature, the committee found that NAION is a very rare side effect of GLP-1
