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Important observations All five clinical trials that were included in the analysis reported GLP-1 receptor agonist-mediated reduction in substance use disorder, with two trials respectively reporting a significant therapeutic impact of GLP-1 receptor agonist in reducing alcohol use disorder and nicotine use disorder

Additionally, GLP-1RA dosage exhibits a dose-dependent effect on cancer risk modulation

Marx, H

Consistently, GLP-1RA use was associated with a lower recurrence risk than insulin/metformin use

How it works Clinical evidence Comparison with other GLP-1s Market outlook References Further reading Orforglipron, the first promising oral small-molecule GLP-1, is demonstrating weight-loss and metabolic results that could reshape obesity treatment and challenge injectable standards