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Over 80% experienced at least a 5% reduction in their body weight

Its cardiovascular and renal R&D leaders, speaking on Scrips Five Must-Know Things, argued that GLP-1 drugs very limitations create the opening for their pipeline

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Primary outcomes were 5% total weight loss (TWL) at 12-months post initiation, and IBD flares, comparing 12-months pre- and post-GLP-1 RA initiation

While some studies found no difference between individuals with T2DM and matched non-diabetic controls (6769), others found plasma DPP-4 activity to be reduced in the patients, and suggested this might reflect a compensatory response to the reduced insulin sensitivity and hyperglycaemia, in an attempt to increase intact incretin hormone concentrations and improve insulin secretion (70, 71)