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A New Indication for Semaglutide (Wegovy) The injectable glucagon-like peptide-1 (GLP-1) receptor agonist semaglutide (Wegovy) has been approved by the FDA to reduce the risk of major adverse cardiovascular events (MACE) in adults with established cardiovascular disease (CVD) and either obesity or overweight

Today, we announced new data from the latest Phase 3 study of retatrutide, an investigational triple hormone receptor agonist being studied for adults living with obesity or overweight with at least one weight-related comorbidity

It also raises the risk of sarcopenia the age-related loss of muscle mass and function that contributes to frailty, falls, and reduced quality of life

In clinical practice, drug selection should therefore prioritize factors such as tolerability, safety profile, adherence, cost, and patient preference rather than expecting major differences in cardiovascular efficacy.

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