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For patients whose primary driver is toxic load or a fundamentally caloric imbalance, GLP-1 will do less, not because its failing, but because it was never aimed at their actual problem

In the treatment-policy estimand analysis, at week 26 oral semaglutide (1.2% mean A1C reduction from baseline) met criteria for noninferiority when compared with liraglutide (1.1% mean A1C reduction from baseline) and met criteria for superiority when compared with placebo (0.2% mean A1C reduction from baseline

however, these agents frequently impose a substantial metabolic burden, manifesting as weight gain, insulin resistance (IR), dysglycemia, dyslipidemia, and hypertension

In terms of the reduction in levels of free testosterone, 3 studies (with 39 and 41 subjects from the experimental and control groups, respectively) were included in the analysis

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