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[DOI] [PMC free article] [PubMed] [Google Scholar] 72.Le K.D.R., Le K., Foo F

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Tirzepatide, a newer GLP-1/GIP receptor agonist, activates two separate appetite pathways rather than one, making it effective for patients who've stopped responding to single-agent GLP-1 therapy

Fatigue, drowsiness, and daytime sleepiness do show up for some users, but they are not universal

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