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There is also a separate safety question, distinct from efficacy: retatrutide raises resting heart rate by 5 to 10 beats per minute, which has not yet been characterised in patients who already have heart failure or irregular heartbeats

Risk of wrist fracture, estimated by the load-to-strength ratio, declines following sleeve gastrectomy in adolescents and young adults

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These medications work by slowing gastric emptying and increasing feelings of fullness, which can lead to a weight loss of 1015%