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Such effect was not seen in previous studies but most of them were conducted in healthy men

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In a randomized clinical trial published in JAMA Psychiatry, semaglutide reduced alcohol craving and improved some drinking outcomes versus placebo in adults with alcohol use disorder

Recently, the concept of functional selectivity or ligand bias has emerged whereby ligand binding promotes engagement of only a particular subset of the full GPCR signalling repertoire to the exclusion of others 11
Research suggests it might be more effective than medications that target only GLP-1
