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The GRADE framework assesses the quality of evidence across five domains: risk of bias, directness of evidence, heterogeneity, precision of effect estimates, and risk of publication bias

They are not the same as brand-name FDA-approved medications like Ozempic, Wegovy, Mounjaro, or Zepbound

Abnormalities in energy metabolism may underlie the vulnerability of dopaminergic neurons in the substantia nigra of PD patients (26)

Support includes preclinical binge eating models showing efficacy of GLP-1 and analogues, evidence of altered GLP-1 levels in BED/BN, preliminary human data with abnormal eating

What Does GLP-1 Weight Loss Treat