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doi: 10.3389/fnins.2015.00387

While obesity has been recognized as a chronic disease requiring ongoing management , when GLP-1 medications are discontinued, healthy behaviors are also essential for long-term weight maintenance. Research indicates that after one year, two-thirds of people end up regaining weight

Upon infusion, GLP-1 exerts potent vasodilatory effects on conduit artery and arterioles in healthy humans leading to increased blood flow for enhanced microvascular recruitment and muscular perfusion 46

Both drugs share common, generally mild-to-moderate gastrointestinal side effects (nausea, vomiting, diarrhea) common to all incretin-based therapies

By including more RCTs, our meta-analysis strengthens the evidence provided by Popovic et al