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Moreover, conditioned media from activated fibroblasts and exogenous lactate have been shown to trigger the expression of profibrotic genes in macrophages by inducing histone lactylation [17]
[DOI] [PMC free article] [PubMed] [Google Scholar] 102.Gallwitz B., Guzman J., Dotta F., Guerci B., Simo R., Basson B.R., Festa A., Kiljanski J., Sapin H., Trautmann M., et al
9 How Are GLP-1 Types Used
NHS Access Pathway: Consult your GP to discuss whether GLP-1 treatment is appropriate for your condition
It is also worth investigating pathways that GLP-1RAs may affect in the pathophysiology of lymphedema as it is unclear whether their potential effects are related to weight loss alone or interactions with known inflammatory pathways of lymphedema
