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& Hoole, S

Diarrhea and constipation are also commonly observed, each potentially affecting ten to fifteen percent of patients, with individual susceptibility varying based on factors such as baseline gastrointestinal function, dietary habits, and concurrent medications

however, when rigorously designed using proven analytic approaches to emulate reference trials, real-world evidence of several glucose-lowering drug classes have demonstrated strong concordance with trial estimates 20,22,32

long after the meds are done

Because the fraction was incapable of decreasing blood glucose, Kimball and Murlin hypothesized that the hyperglycemic effect resulted from a secreted factor, one that antagonizes insulin's hypoglycemic effect