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Much anticipated Phase II results in obesity for Amgens GLP-1 agonist/GIP antagonist showed up to 20% weight loss, but without detailed data the drugs competitiveness is hard to ascertain.

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Combining the therapeutic approaches of GLP-1 agonists (which target extrahepatic mechanisms for metabolic disorders) with resmetirom (which target intrahepatic mechanisms for MASH and liver fibrosis) seems like a promising strategy for addressing fat accumulation, inflammation, and fibrosis associated with MASH.

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