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By improving insulin sensitivity, GLP-1 RAs may reduce hyperinsulinemia-driven androgen production and help restore ovulatory cycles.47, 48, 49 A meta-analysis in women with polycystic ovary syndrome and overweight or obesity found that GLP-1 RA use was associated with improvements in menstrual regularity (standardized mean difference: 1.72, 95% CI 0.60, 2.85) compared to metformin or placebo, and spontaneous pregnancy rate (RR: 1.72, 95% CI 1.22, 2.43) compared to metformin

Dapagliflozin currently has the lowest eGFR cut off for the indication of CKD at above 25 mL/min/1.73 m 2

Glucagon Activation Increased energy expenditure, hepatic fat oxidation, and basal metabolic rate, expanding the therapeutic mechanism beyond appetite alone

This weight loss was achieved with diet and exercise alone which seems like a much better solution

Now, Fraser wishes they could have experienced pregnancy and childbirth while living openly as a nonbinary transgender man, they write in a First Opinion essay