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-endorphin expression was mediated through autocrine activation of the IL-10 receptor- and downstream phosphorylation of STAT3 [63]

Patients discontinuing GLP-1 medications should monitor for signs of gallbladder problems (severe abdominal pain, especially after meals), pancreatitis (persistent severe abdominal pain, sometimes with vomiting), or significant hyperglycemia

Furthermore, many drugs used to treat diabetes, such as SUs, TZDs, and insulin, are associated with weight gain