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Niacinamide, also known as nicotinamide or vitamin B3, serves two purposes in the formulation

Why its interesting: The ingredients arent new, but the delivery system and direct GLP-1 positioning give it a unique angle

Reminder that most autoimmune or inflammatory diseases, from psoriasis to Addisons disease to lupus to scleroderma to inflammatory bowel disease, have been shown to have elevated cardiovascular risk Ongoing randomized trials including ZEUS, HERMES, and ARTEMIS will inform whether novel targeting of IL-6 can safely lower cardiovascular event rates or slow renal progression Show notes Targeting Inflammation for Cardiovascular Risk Why is it important to measure both LDL and hs-CRP, and what factors increase hs-CRP

When Eli Lilly published retatrutide's Phase 2 trial results in the New England Journal of Medicine in June 2023, the numbers got attention: participants on the highest dose lost an average of 24.2% of their body weight over 48 weeks

Immune System Support: A healthy gut microbiome is crucial for a robust immune system