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however, a new paradigm for HFpEF development proposes that a systemic proinflammatory state, induced by comorbidities, is responsible for these myocardial structural and functional changes [11]

17 Therefore, when designing a dual agonist, either His or Tyr can be chosen for position 1 by weighing the required GLP-1 and GIP activity, and Phe is also worth considering

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Counsel on dose escalation schedule, side effects and red-flag symptoms

Abstract Aims/hypothesis Glucagon-like peptide-1 receptor agonists (GLP-1ras) and sodiumglucose cotransporter 2 inhibitors (SGLT2is) have shown kidney-protective effects