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The anorectic and thermogenic effects of estradiol can be direct, through genomic and non-genomic mechanisms, or indirect, through activation of peripheral mediators such as cholecystokinin (CCK), insulin, leptin and GLP-1

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However, there is evidence to suggest that the injections may affect the effectiveness of oral contraceptives [14], and they are not suitable to be taken while pregnant or breastfeeding

[DOI] [PMC free article] [PubMed] [Google Scholar] 183.Wolosowicz M., Lukaszuk B., Chabowski A
