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[8,16] Once activated, Akt regulates several crucial downstream mechanisms, including glucose uptake through GLUT3/GLUT4 transporters, stabilization of neuronal membrane potential through Na + /K + -ATPase activity, modulation of GABAergic neurotransmission, and regulation of mitochondrial function through mammalian target of rapamycin (mTOR) and AMP-activated protein kinase (AMPK) pathways

However, the precise distribution, trafficking, and surface accessibility of GLP-1R on immune cells remain incompletely characterized

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The extent varies depending on age, genetics, baseline facial volume and the pace of weight reduction

Diabetes 2014;63:e4