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The combination of rapid fat loss, increased oxidative stress on skin cells, and reduced hydration creates the perfect conditions for sagging, crepiness, and rough texture

Drug discontinuation due to side effects was 10% at the 15 mg dose, the highest of any dose

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This reinforces that while retatrutide mood changes are a hot topic on social media, the clinical data suggests these medications are generally safe for mental health when used under medical supervision

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