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The market had changed enough by the time the institute revisited the topic in 2025 and found some drugs cost-effective at certain prices and formulations

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Semaglutide is an FDA-approved GLP-1 receptor agonist, specifically developed for chronic weight management in adults dealing with obesity or overweight conditions

Methods Dataset curation Reddit is a popular social media platform that is composed of communities called subreddits, which are prefixed by r/ and are focused on specific topics (e.g., r/AskDoctors and r/WorldNews)

How Direct Meds compares to brand-name pricing For context, here is what brand-name semaglutide costs without insurance: Ozempic: approximately $997 per month Wegovy: approximately $1,349 per month Rybelsus (oral): approximately $936 per month Direct Meds compounded semaglutide at $249 to $297 per month represents roughly a 70 to 75 percent cost reduction compared to brand-name options