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By mimicking the actions of the hormone GLP1, these agents improve blood glycaemic control by increasing glucose-dependent insulin secretion, decreasing inappropriate glucagon secretion, and regulate appetite (by increasing satiety and delaying gastric emptying) to promote weight loss

Any concerning cognitive symptoms warrant clinical evaluation to exclude other causes, and the risk-benefit balance of continuing GLP-1 therapy should be individually assessed

The findings, published in the journal Diabetes, Obesity and Metabolism, provide real-world context to previous randomized clinical trials indicating that patients who stopped semaglutide (sold under the brand names Ozempic/Wegovy) and tirzepatide (sold under the brand names Mounjaro/Zepbound) regained more than half of the weight they lost within 12 months

As The New Yorker has observed, the rise of GLP-1s marks a shift not only in medicine but in cultureas appetite-modulating drugs move from treating diabetes toward shaping body ideals, identity, and social aspiration

An honest word on evidence and framing before we go further: semaglutide is a prescription, FDA-approved drug (marketed as Wegovy for weight management and Ozempic for type 2 diabetes)