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In patients with type 2 diabetes mellitus, metagenomic analyses reveal that GLP-1RAs induce structural and functional remodeling of gut microbial communities, ameliorating dysbiosis and improving host metabolic homeostasis (Shang et al., 2021)

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Glucagon-receptor activation contributes effects on hepatic lipid metabolism and whole-body energy expenditure that are absent from GLP-1 mono-agonists and dual GLP-1/GIP agonists

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