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Patients taking bupropion for smoking cessation may also experience changes in mood, psychosis, hallucinations, paranoia, delusions, homicidal ideation, hostility, aggression, anxiety, and panic, as well as suicidal ideation, suicide attempt, and completed suicide, high blood pressure, fast, irregular heartbeats, seizures, acute angle-closure glaucoma, and death

Without enough mitochondrial capacity to burn those fatty acids efficiently, they get recirculated and re-deposited, or worse, they overwhelm tissues that cant handle the load (a process called lipotoxicity)

Andrew Adams, Group Vice President of Molecule Discovery and Director of the Lilly Institutes of Genetic Medicine at Eli Lilly, concluded his presentation on the GLP-1 story with a seismic question: "Are GLP-1s the world's first longevity drug?" It was a watershed moment