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doi: 10.1007/s00125-017-4330-3

Beyond obesity and type 2 diabetes, the therapeutic potential of GLP-1 RAs extends to a range of conditions such as cardiovascular disease, liver disease, neurodegenerative disease, and substance abuse disorders

Theres often very little follow-up, minimal education around behavior change, and not much focus on body composition or long-term metabolic health, says Class

However, over the course of the last few years, Pfizer discontinued danuglipron, lotiglipron, and PF-06954522, the first two due to concerning liver enzyme elevations seen in clinical studies

In an attempt to manage GLP-1 costs, the plan considered tightening prior authorization criteria to limit GLP-1 approval for weight loss to only those with extreme obesity