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These effects were coupled to an amelioration in lipid metabolism and hepatic steatosis, which markedly exceeded the effect of single GLP-1RA treatment ( Oxyntomodulin, a gut-derived peptide hormone, activates both the GLP-1R and the GCGR, although, with reduced affinity compared to GLP-1 and glucagon, respectively

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[DOI] [PubMed] [Google Scholar] 80.Garvey W.T., Frias J.P., Jastreboff A.M., le Roux C.W., Sattar N., Aizenberg D., Mao H., Zhang S., Ahmad N.N., Bunck M.C., et al