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It is also interesting to note that animal studies have shown that GLP-1 and GLP-1 RAs can expand beta-cell mass by reducing beta-cell apoptosis and stimulating beta-cell proliferation and beta-cell neogenesis (differentiation of beta cells from ductal progenitor cells) [85,86,87,88]

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Statistical Solutions, Cork, Ireland): this calculation indicates that to rule out a risk for acute pancreatitis elevated by at least 25%, a prospective randomized clinical trial with ~89,000 patient-years of observation would be necessary per group (GLP-1 receptor agonist, DPP-4 inhibitor, or control medication)