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Moreover, DPP-IV is expressed on various immune cells, including T lymphocytes

According to the MHRA/EMC SmPC for Wegovy, the most frequently reported gastrointestinal side effects include: Nausea the most common adverse effect, affecting approximately 44% of patients in clinical trials, typically most pronounced during dose escalation Diarrhoea reported in around 30% of patients, ranging from mild to moderate severity Constipation affecting approximately 24% of patients, related to slowed gut transit Vomiting occurring in roughly 24% of patients, often associated with nausea Abdominal pain or discomfort reported by approximately 20% of patients Dyspepsia (indigestion) affecting around 9% of patients Bloating and flatulence commonly reported but less precisely quantified in trials These side effects are dose-dependent , meaning they tend to be more pronounced at higher doses and during the escalation phase

But we found this story to be so compelling that we opted to publish this part of the story now

We're talking studies with hundreds of thousands of people, some cases over a million, that point to something I think most people who lived, us, I hope, or if you just came across this podcast, you're going to be motivated to do that, have never really thought too much about

This can be especially unpleasant when youre taking semaglutide, as the medication is already linked to GI side effects like abdominal pain, constipation , diarrhea, nausea , and vomiting