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(13) applied multiple techniques, including region-specific injections of GLP-1R antagonists, lesioning specific nerves and nuclei, ex vivo electrophysiological studies, and peripheral administration of a fluorescently labeled liraglutide molecule in rats, WT mice, and Glp1r / mice to dissect mechanisms that link peripheral administration of a GLP-1R agonist to reduced food intake and weight loss
To our knowledge, no preclinical investigation has reported the efficacy of the GLP-1R agonist SEMA in treating diabetic neuropathic pain
It has demonstrated significant weight loss in patients with and without type 2 diabetes
