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Chronic colonic delivery of propionate, for example, has been associated with reduced body weight and liver fat accumulation in experimental and early human studies

This process, known as demyelination, results in nerve cell damage

However, animal models have significant limitations in predicting human autoimmune disease responses

Int J Clin Pract 70(8):649656 Yaribeygi H, Farrokhi FR, Abdalla MA, Sathyapalan T, Banach M, Jamialahmadi T, et al (2021) The effects of glucagon-like peptide-1 receptor agonists and dipeptydilpeptidase-4 inhibitors on blood pressure and cardiovascular complications in diabetes

To date, tens of thousands of research participants have received GLP-1RAs in RCTs investigating efficacy for improving glycemic control, body weight, and cardiovascular outcomes