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Path 2: Gradual taper and discontinuation For patients who have made substantial lifestyle changes and want to attempt life without medication, a structured taper offers the best chance of success

Is Rybelsus a GLP-1

The next few years will be critical in shaping this new landscape

Opioid use may worsen gastric retention Higher prevalence of recent opioid use in the high RGC group Suggests an additive effect on gastric motility No difference in indication or duration of therapy Whether patients used GLP-1 RAs for diabetes or weight loss did not affect risk Duration of therapy was not a significant predictor Interpretation Withholding 7.5 days higher risk of retained gastric contents Fasting 21.3 hours strongest predictor of high RGC These thresholds optimize sensitivity and specificity for detecting risk