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Semaglutide therapy for metabolic dysfunction-associated steatohepatitis: November 2025 updates to AASLD practice guidance

In contrast, in primate and human thyroids, GLP-1R has either not been detected (74) or only found in small fractions of healthy C cells (75), and treatment with liraglutide does not stimulate calcitonin secretion (76)

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The six-month gap between scheduled follow-ups is longer than most clinics, which could be unsettling for patients who want more regular oversight

The 6-month and 12-month cohorts were treated independently, so that any given individual could be included in either cohort, or in both, provided they had data available at the relevant time points