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Additionally, empagliflozin is also seen as a suitable option for patients with coexisting conditions

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Male-specific metabolic factorsincluding higher baseline muscle mass and faster resting metabolic ratesmean that weight loss trajectories may differ slightly from female populations

Recently, a phase II multicentre, double-blind, randomized controlled trial including 338 adults with obesity were administered retatrutide (1, 2 mg starting dose increased to 4, 2 mg starting dose increased to 8, 2 mg starting dose increased to 12 mg) compared to placebo over 48 weeks [64]

Other actions of GLP-1 that also contribute to restoring glucose regulation in Type 2 diabetes include inhibition of glucagon secretion, slowing of gastric emptying, suppression of appetite and modest reduction in body weight (37, 48, 84, 118)