history of glp 1 agonists glp-1_analogs [TUSOM american diabetes association pancreatitis history

10.2337/dc14-2364 85

DozioEVianelloEMalavazosAETacchiniLSchmitzGIacobellisGet alEpicardial adipose tissue GLP-1 receptor is associated with genes involved in fatty acid oxidation and white-to-brown fat differentiation: a target to modulate cardiovascular risk

However, some scholars have proposed that the effect of GLP-1 in the liver is indirectly mediated by multiple mechanisms, such as reducing fat absorption or inhibiting fat cells through acyl-CoA synthetase long chain family member 1 (ACSL1), CCAAT/enhancer binding protein (C/EBP), peroxisome proliferator-activated receptor- (PPAR), and sterol regulatory element binding protein-1c (SREBP-1c) pathways to achieve the purpose of reducing liver lipids [38]

Standards of care in diabetes2026 [Internet]

2.3 Data extraction and risk of bias assessment Two independent reviewers (IR and SK) extracted the following data using a pre-tested form: Author name, publication year, country of origin