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Description
The emergence of new medications and combination therapies may further fragment the market, driving down prices and restricting the market share for GLP-1 receptor agonists

Additionally, changes in blood glucose levels may play a role

Davies, E

The initial phase of GLP-1 secretion occurs rapidly, within 1015 minutes of eating, even before nutrients reach the distal intestine where most L-cells reside

Proinflammatory cytokines in response to insulin-induced hypoglycemic stress in healthy subjects