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doi: 10.1074/JBC.RA120.014368/ATTACHMENT/1ADDD840-B412-47EC-97D3-82859E79F5CE/MMC1.PDF
Effect of glucagon-like peptide-1 receptor agonists on lipid profiles among type 2 diabetes: A systematic review and network meta-analysis
Unfortunately, GLP-1 is rapidly degraded by the enzyme dipeptidyl peptidase-4 (DPP-4), which limits the therapeutic efficacy of native GLP-1 (Deacon et al., 1995)
The same effect of liraglutide was revealed in another study in patients with diabetes and hypertension but without renal impairment 27
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