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3.2 GM and hormone metabolism disorders Hyperandrogenemia (HA) is also a pivotal clinical manifestation in patients with PCOS, potentially stemming from complex interplays involving the Hypothalamic-pituitary-gonadal (HPG) axis, adrenal function abnormalities, dysregulation of glucose and lipid metabolism, intestinal microbiota imbalances, chronic inflammation, and genetic predispositions (39)

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Lateral allosterism in the glucagon receptor family: Glucagon-like peptide 1 induces G-protein-coupled receptor heteromer formation

doi: 10.1016/j.bbrc.2013.06.035