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11/03/2025 Electronic publication Footnotes Conflict of interest: DJD has received consulting fees from Anylam, Amgen, AstraZeneca Inc., Crinetics, Eli Lilly, Insulet, Kallyope, Metsara, and Pfizer Inc

Up-regulation of glutamate receptors is associated with LTP defects in the early stages of diabetes mellitus

Easier to recover from on GLP-1 drugs: Moderate-intensity resistance training with controlled tempo (3-second eccentric) Lower total volume sessions (8 to 12 working sets) Walking and low-intensity steady-state cardio Mobility and flexibility work Harder to recover from on GLP-1 drugs: High-volume bodybuilding-style sessions (20+ sets) High-intensity interval training (HIIT) Heavy eccentric-focused training (slow negatives, drop sets) Two-a-day training sessions Endurance workouts over 60 minutes at moderate-to-high intensity The common thread: anything that creates significant muscle damage or glycogen depletion will take longer to recover from when calories are restricted

At Mayfair Weight Loss Clinic, treatment is guided by qualified clinicians with ongoing monitoring, so any decisions around donation can be made with confidence and aligned with safe, responsible care

Role in Obesity Treatment: GLP-1 plays a vital role in obesity treatment due to its effects on appetite regulation and its ability to promote weight loss