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In murine pancreatic Min6-K8 cells, prevention of cytosolic glutamate production by KO of a key component of the malate-aspartate shuttle or triple KO of the vesicular glutamate transporters Slc17a6, Slc17a7, and Slc17a8 impaired GLP-1-induced insulin secretion [515]

The result is pain

New GLP-1 research from Omada Real-world studies have shown 1/3 of people stop GLP-1s in the 1st month

Documentation: A clear timeline connecting the initiation or dosage increase of the GLP-1 drug to the onset of symptoms

In the STEP 4 and SURMOUNT-4 trials funded by Novo Nordisk and Eli Lilly where patients abruptly discontinued medication, many of them were not at a normal BMI at withdrawal and regained most of the weight they lost