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Importantly, as many of the aforementioned studies availed direct central drug application, thereby bypassing peripheral metabolism, the resulting sex differences are separable from potential differences in peripheral drug metabolism, BBB crossing, body weight, or fat depot differencesall important factors that add another layer of complexity when interpreting sex differences considered in clinical data

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Ive pointed patients to Noom for exactly that reason, and now that the GLP-1 Companion is free, its something I can offer everyone I start on these medications