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Cell-based studies are powerful for mechanism-focused research, but they have limits

Common symptom pattern: what most people experience For many people the pattern is predictable: a higher-fat meal plus a correctly timed dose equals the classic orlistat experience - oily stools, increased gas with oily spotting, or sudden urgency

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In many common concentrations, 50 units represent a high therapeutic dose, and exceeding this without medical guidance can lead to severe side effects

"Our goal is to move the field toward effective, accessible treatments that can slow or even reverse liver damage before patients reach liver failure." Co-authors include Jacob George, Westmead Institute for Medical Research