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Description
The dual-receptor concept, often called the twincretin approach, was built on preclinical observations that GIP and GLP-1 contribute complementary insulinotropic and satiety-related signaling in rodent models
They also protect against mitochondrial dysfunction, preventing the release of Cytochrome c and stabilizing mitochondrial membranes, thereby inhibiting apoptosis
On average, breastfeeding mothers need about 2,000 calories per day plus an additional ~250 calories for milk production sometimes more depending on body size and milk output
doi: 10.1053/j.gastro.2010.01.049
UC, ulcerative colitis
