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Substituting two to three residues in the N-terminal part of GLP-1 by corresponding residues from glucagon (Ala 8 Ser/Glu 9 Gln), peptide histidine isoleucine (Glu 9 Asp/Thr 11 Ile), or PACAP (Ala 8 Ser/Glu 9 Asp/Thr 11 Ile), in contrast, had only small effects on affinity for GLP-1R

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