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These products are not interchangeable and should not be used outside of their approved indications

If a teen weighs 400 pounds and loses 20 to 60 pounds on a GLP-1 medication, I have to ask, Are you going to be happy at over 300 pounds? Bariatric surgery provides more weight loss than the GLP-1 medications do

We identify a missense variant in GLP1R that is associated significantly with increased efficacy of GLP1 medications ( P = 2.9 10 10 ), with an additional 0.76 kg of weight loss expected per copy of the effect allele

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Patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 should not receive GLP-1 agonists