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Description
27 In the pancreas, GLP-1 receptor (GLP-1R) activation in islet cells promotes glucose-dependent insulin secretion from -cells, 28 inhibits glucagon release from -cells, and suppresses exocrine function via induction of pancreatic somatostatin

The trial, conducted across multiple international sites and involving 725 adults living with obesity or overweight but without type 2 diabetes, concluded in April 2026 after 76 weeks of treatment

doi:10.1016/j.hpb.2018.09.017 16

Van Cauwenberghe et al

These habits can help maintain weight loss long term, even without the medications effects, and make it less likely for the pounds to return
