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Risk ratios (RR) for nonfatal stroke estimates according to direct (DPP-4 inhibitors, GLP-1RA and SGLT-2 inhibitors against placebo) and indirect (DPP-4 inhibitors vs GLP-1RA or SGLT-2 inhibitors, and GLP-1RA vs SGLT-2 inhibitors) comparisons
However, Eli Lilly's existing GLP-1 franchise generated $36.5 billion in 2025, analysts project retatrutide could add $15+ billion annually, and the combined obesity drug market is projected to reach $101 billion in peak annual sales
124 They were found to have EC 50 values ranging from 50 to 1000 nM in cAMP response element (CRE) luciferase reporter assays
