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A broad spectrum of secondary measures was additionally evaluated in this double-blind exenatide PD clinical trial, 47 and although none demonstrated statistical significance following correction for multiple comparisons, the majority were in the direction favoring an exenatide advantage

Important Safety Information for RYBELSUS WARNING: RISK OF THYROID C-CELL TUMORS In rodents, semaglutide causes dose-dependent and treatment-duration-dependent thyroid C-cell tumors at clinically relevant exposures

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[DOI] [PubMed] [Google Scholar] Goland R, Freeby M, Parsey R, Saisho Y, Kumar D, Simpson N, Hirsch J, Prince M, Maffei A, Mann JJ, et al

While the inherent mechanism of action of GLP-1R agonists mediates their glucose dependence, studies in rats suggest that SUs may uncouple this dependence